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Creamy Spinach and Artichoke Chicken Casserole in a skillet with tender chicken, melted cheese, spinach, and artichokes.

Spinach and Artichoke Chicken Casserole


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  • Author: Aneta
  • Total Time: 50 minutes
  • Yield: 6 servings 1x

Description

This creamy Spinach and Artichoke Chicken Casserole is the ultimate comfort-food dinner—packed with tender chicken, rich cheeses, spinach, and artichokes. Simple to make, incredibly flavorful, and perfect for busy weeknights or cozy family meals.


Ingredients

Scale
  • 3 cups cooked chicken, shredded or diced

  • 1 can artichoke hearts, drained and chopped

  • 1 cup frozen chopped spinach, thawed and drained

  • 1 cup mayonnaise

  • 1 cup sour cream

  • 1 ½ cups shredded mozzarella cheese, divided

  • 1 ½ cups grated Parmesan cheese, divided

  • 1 tsp garlic powder

  • 1 tsp onion powder

  • ½ tsp black pepper

  • ½ tsp salt

  • 1 tbsp olive oil (for greasing)

  • 1 cup breadcrumbs

  • 3 tbsp melted butter


Instructions

  1. Preheat oven to 375°F (190°C).

  2. In a large bowl, combine chicken, artichoke hearts, and drained spinach.

  3. Add mayonnaise, sour cream, ¾ cup mozzarella, ¾ cup Parmesan, garlic powder, onion powder, black pepper, and salt. Mix well.

  4. Lightly grease a 9×13-inch baking dish with olive oil.

  5. Spread the mixture evenly into the baking dish.

  6. In a small bowl, mix breadcrumbs with melted butter until fully coated.

  7. Sprinkle breadcrumb topping evenly over the casserole, then top with remaining mozzarella and Parmesan.

  8. Cover with foil and bake for 20 minutes.

  9. Remove foil and bake an additional 10–15 minutes, until golden and bubbling.

  10. Let cool slightly before serving.

Notes

  • For a shortcut, use shredded rotisserie chicken.

  • Squeeze spinach very well to prevent excess moisture.

  • Add red pepper flakes for a spicy kick.

 

  • Can be assembled up to 24 hours ahead and baked later.

  • Prep Time: 15 minutes
  • Cook Time: 35 minutes
  • Category: Dinner, Casserole
  • Method: Baking
  • Cuisine: American

Nutrition

  • Serving Size: 1 portion
  • Calories: 520 kcal
  • Sugar: 3 g
  • Sodium: 820 mg
  • Fat: 38 g
  • Saturated Fat: 14 g
  • Unsaturated Fat: 21 g
  • Trans Fat: 0 g
  • Carbohydrates: 14 g
  • Fiber: 3 g
  • Protein: 32 g
  • Cholesterol: 135 mg