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High Protein Spinach Artichoke Chicken Casserole served in a white bowl with creamy spinach, artichokes, tender chicken, and toasted bread on the side.

High Protein Spinach Artichoke Chicken Casserole 


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  • Author: Aneta
  • Total Time: 40 minutes
  • Yield: 6 servings 1x

Description

This High Protein Spinach Artichoke Chicken Casserole is creamy, cheesy, and packed with lean chicken, Greek yogurt, spinach, and artichokes. It’s the perfect high-protein comfort meal for busy weeknights—easy to prep, family-friendly, and ready in about 40 minutes.


Ingredients

Scale
  • 2 cups cooked chicken, shredded
  • 1 cup fresh spinach, chopped
  • 1 can (14 oz) artichoke hearts, drained and chopped
  • 1 cup plain Greek yogurt
  • 1 cup shredded mozzarella cheese, divided
  • 1/2 cup grated Parmesan cheese, divided
  • 2 cloves garlic, minced
  • 1 teaspoon onion powder
  • 1 teaspoon dried oregano
  • Salt, to taste
  • Black pepper, to taste

Instructions

  1. Preheat oven to 375°F (190°C).
  2. In a large bowl, combine shredded chicken, spinach, chopped artichokes, Greek yogurt, half of the mozzarella, half of the Parmesan, garlic, onion powder, oregano, salt, and pepper.
  3. Stir until fully combined and evenly coated.
  4. Transfer mixture into a greased 9×13-inch baking dish and spread evenly.
  5. Sprinkle remaining mozzarella and Parmesan over the top.
  6. Bake for 25–30 minutes, until cheese is bubbly and golden brown.
  7. Let rest 5–10 minutes before serving.

Notes

  • Rotisserie chicken works great for convenience.
  • If using frozen spinach, thaw and squeeze out excess moisture first.
  • Store leftovers in an airtight container for up to 4 days.
  • Freeze up to 2 months for meal prep.
  • Prep Time: 10 minutes
  • Cook Time: 30 minutes
  • Category: Dinner
  • Method: Baking
  • Cuisine: American

Nutrition

  • Serving Size: 1 serving (about 1 cup)
  • Calories: 320 kcal
  • Sugar: 3 g
  • Sodium: 520 mg
  • Fat: 14 g
  • Saturated Fat: 6 g
  • Unsaturated Fat: 7 g
  • Trans Fat: 0 g
  • Carbohydrates: 6 g
  • Fiber: 2 g
  • Protein: 38 g
  • Cholesterol: 95 mg