Can I substitute the biscuits?

You can use homemade biscuit dough, but the refrigerated biscuits keep things easy. Crescent dough works in a pinch, but the texture will be softer.

Can I make this ahead of time?

Yes! Prep everything, but wait to add the biscuits until just before baking. Otherwise, they get soggy and lose their “bubble.”

How do I store leftovers?

Leftovers last 3–4 days in an airtight container in the fridge. To reheat, pop it in the oven or microwave. Add a splash of milk before reheating if it seems dry.

Can I freeze this casserole?

Yes—but freeze it before baking. Wrap tightly and freeze for up to 3 months. Thaw in the fridge overnight, add biscuits, then bake as directed.

Can I use different vegetables?

Absolutely. This is your casserole—customize it based on your family’s favorites or what’s hiding in the freezer.

Chicken Bubble Biscuit Bake Casserole: 5 Irresistible Comfort Bites

Description

This cozy and creamy Chicken Bubble Biscuit Bake Casserole is the ultimate weeknight comfort meal—fluffy golden biscuits, tender chicken, melty cheese, and savory herbs all baked together into a warm, bubbly dish your whole family will love.

Ingredients

Scale

2 cups cooked chicken, shredded or diced (rotisserie works great)
1 (10.5 oz) can cream of chicken soup (or cream of mushroom)
1/2 cup sour cream or plain Greek yogurt
1/2 cup milk
1 cup frozen mixed vegetables (peas, carrots, corn, beans)
1 tsp garlic powder
1/2 tsp onion powder
Salt & pepper to taste
1 (16 oz) can refrigerated biscuit dough, cut into quarters
1 cup shredded cheddar cheese or mozzarella
1 tbsp melted butter (optional, for brushing)

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Instructions

Preheat oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
In a large bowl, mix cooked chicken, soup, sour cream, milk, vegetables, garlic powder, onion powder, salt, and pepper until smooth.
Fold in the quartered biscuit pieces, coating them well in the mixture.
Pour everything into the prepared baking dish and spread evenly.
Sprinkle shredded cheese on top.
Cover with foil and bake for 20 minutes.
Remove the foil and bake an additional 10–15 minutes, or until the biscuits are puffed, golden, and fully cooked.
Brush with melted butter if desired. Let cool slightly before serving.

Notes

Rotisserie chicken adds extra flavor and saves time.
Spread biscuits out as evenly as possible for even baking.
Add a pinch of paprika or red pepper flakes for mild heat.

Leftovers reheat best in the oven or air fryer to keep the biscuits crispy.

Prep Time: 10 minutes
Cook Time: 30–35 minutes
Category: Main course
Method: Baking
Cuisine: American

Nutrition

Serving Size: 1 portion (1/6 of casserole)
Calories: 480 kcal
Sugar: 4 g
Sodium: 1250 mg
Fat: 28 g
Saturated Fat: 12 g
Unsaturated Fat: 14 g
Trans Fat: 0 g
Carbohydrates: 35 g
Fiber: 2 g
Protein: 24 g
Cholesterol: 85 mg